Thanks for the replies- Yes, the master is definitely not set to mono, and like I said it works in headphones but not in speakers.. Solger- let me see.. so the speakers I'm using are pretty basic Logitech speakers, Logitech Z313 to be exact. I'm not quite sure what you mean by the soundcard of the computer or a different audio interface? I just plug in the speaker jack into my computer and run it into the computer speakers.. I'm using a Dell PC and on the side of the computer it has one output with the headphone symbol and one for speakers.. In Reaper, under my 'Device', 'Output' setting, I have the option selected for 'DX speakers' or something like that- one of the few options the built-in settings offered.. Let me know if that makes sense. Thanks again!